Scientific Studies to Support the use of REPARAGEN
REPARAGEN is a combination of patented and patent-pending ingredients that act in a synergistic manner. The studies reflect the research on the individual components.
Further information can be accessed through PubMed where you can conduct literature searches.
Alternatively you may wish to use Open Access publishers like BioMed Central which allows free access to scientific publications.
REPARAGEN (previously called IGFlex)
- Miller MJS, Ahmed S, Bobrowski P, Haqqi TM. Transcriptional Activation of IGF-1 Production in Human Cartilage Explants Concomitant with the Prevention of IL-1 induced Catabolism by a Natural Product Extract, IGFlex. Inflammation Res 2005, 54: S115.
- Miller MJS, Ahmed S, Bobrowski P, Haqqi TM. The chondroprotective actions of a natural product are mediated by the activation of IGF-1 production by human chondrocytes despite the presence of IL-1b. BMC Complementary and Alternative Medicine 2006, 6:13 (7 April 2006).
http://www.biomedcentral.com/1472-6882/6/13/abstract
These studies describe the research breakthrough that constitutes REPARAGEN (activation of repair concomitant with blockade of damaging inflamamtion), which was presented at the World Congress of Inflammation.
REPARAGEN Components
Vincaria
- Miller, MJS, Ahmed S, Bobrowski, P, Haqqi TM. Suppression of human cartilage degradation and chondrocyte activation by a unique mineral supplement (SierraSil) and a cat's claw extract, Vincaria. J Amer Nutra Assoc 2004: 7; 32-39.
Demonstration that vincaria in combination with a mineral supplement reduces human cartilage breakdown and chondrocyte activation induced by Interleukin-1. (Download PDF #2)
- Miller MJS, Angeles FM, Reuter BK, Bobrowski P, Sandoval M. Dietary antioxidants protect gut epithelial cells from oxidant induced apoptosis. BMC Complementary & Alternative Medicine 2001, 1:11. (Download PDF #3)
Vincaria demonstrated protected epithelial cells from various oxidants stresses in a manner that was more effective than vitamin C.
- Sandoval M, Okuhama NN, Zhang X-J, Condezo LA, Lao J, Angeles FM, Bobrowski P, Miller MJS. Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine, 9: 325-337, 2002 (Download PDF #4)
Species devoid of oxindole alkaloids shown to be more effective as anti-inflammatory agents and antioxidants that those with oxindole alkaloids.
- Piscoya J, Rodriguez Z, Bustamante S, Miller MJS, Sandoval M. Efficacy and safety of freeze dried cat's claw in osteoarthritis of the knee: mechanisms of action of the specie Uncaria guianensis. Inflammation Research. 50: 442-448; 2001. (Download PDF #5)
Randomised placebo-controlled clinical trial demonstrating that vincaria reduced the pain and assessments of osteoarthritis of the knee with no adverse events.
- Sandoval M, Charbonnet RM, Okuhama NN, Roberts J, Krenova Z, Trentacosti AM, Miller MJS. Cat's claw inhibits TNF production and scavenges free radicals: role in cytoprotection. Free Radical Biol Med 29: 71-78, 2000 (Download PDF #6)
Potent inhibition of TNF production by vincaria as well as protecting cells from oxidative death including UV radiation.
- Sandoval-Chacon M, Thompson JH, Liu X, Mannick EE, Sadowska-Krowicka H, Charbonnet R, Clark DA, Miller MJS. Anti-inflammatory actions of cat's claw: the role of NF-kB. Alimentary Pharmacology & Therapeutics. 12: 1279-1289, 1998. (Download PDF #7)
Demonstration that vincaria prevents the activation of the transcription factor, NF-kB, and thereby reduces the expression of pro-inflammatory genes. Also describes ability to protect the gut from NSAID damage.
Zangrado & Progrado (Used in topicals)
- Sandoval M, Charbonnet RM, Clark M, Trentacosti AM, Miller MJS. Sangre de grado Croton palanostigma induces apoptosis in human gastrointestinal cancer cells. J Ethnopharmacology, 80: 121-129, 2002. (Download PDF #8)
Demonstration that Sangre de grado can induce apoptosis of cancer cells that involves disruption of cell cytoskeleton.
- Miller MJS, Vergnolle N, McKnight W, Musah RA, Davison CA, Trentacosti AM, Thompson JH, Sandoval M, Wallace JL. Inhibition of neurogenic inflammation by the amazonian herbal medicine, sangre de grado. J Investigative Dermatology 117: 725-730; 2001. (Download PDF #9)
Demonstration that Zangrado is an inhibitor of neurogenic inflammation, is analgesic and effective clinically as a topical in alleviating the bites/stings of insects including fire ants.
- Miller MJS, MacNaughton WK, Zhang X-J, Thompson JH, Charbonnet RM, Bobrowski P, Lao J, Trentacosti AM, Sandoval M. Treatment of gastric ulcers and diarrhea with the amazonian medicinal, sangre de grado. Amer J Physiol 279; G192-G200, 2000. (Download PDF #10)
Demonstration that sangre de grado heals ulcers and reduces the expression of IL-6, Il-1, TNF, iNOS and prevents fluid secretion associated with diarrhea.
Unpublished results indicate that both progrado and zangrado have exceptionally high values for antioxidant activitity. Both have actions to limit neurogenic inflammation and a rich in proanthocyanidins oligomers.
RNI 249
- Sandoval M, Okuhama NN, Lao J, Condezo L, Angeles FM, Miller MJS. Antioxidant properties of an aqueous extract of maca (Lepidium meyenii). Food Chemistry 2002, 79: 207-213. (Download PDF #11)
Demonstration that maca has significant antioxidant potential.
The proprietary ingredients in REPARAGEN are exclusively licensed to Park Labs, LLC from Rainforest Nutritionals, Inc.
The safety and toxicity studies on the components of REPARAGEN and for REPARAGEN itself were performed by Santerra Pharmaceuticals, LLC, a natural products CRO company.
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